Journal article
Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche
NM Castrechini, P Murthi, NM Gude, JJHM Erwich, S Gronthos, A Zannettino, SP Brennecke, B Kalionis
Placenta | W B SAUNDERS CO LTD | Published : 2010
Abstract
The chorionic villi of human term placentae are a rich source of mesenchymal stem cells (PMSCs). The stem cell "niche" within the chorionic villi regulates how PMSCs participate in placental tissue generation, maintenance and repair, but the anatomic location of the niche has not been defined. A number of cell surface markers for phenotypic characterisation of mesenchymal stem cells (MSCs) were employed to identify the stem cell niche within the chorionic villi of first trimester and term human placenta. This included antibodies to pericyte cell surface markers STRO-1 and 3G5, which have been used to identify mesenchymal stem cells in other tissues, but have not been studied in placental tis..
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Grants
Awarded by Cecilia Kilkeary Foundation
Funding Acknowledgements
We wish to acknowledge the financial support of NHMRC Grant No 509178, the RWH Foundation, Cecilia Kilkeary Foundation, Eirene Lucas Foundation, Harold & Cora Brennen Benevolent Trust (Equity Trustees), Jack Brockhoff Foundation, J & R McGaUran Charitable Trust, Diana Brown Trust (Perpetual Trustees), Helen Macpherson Smith Trust, Thomas R & Rosalinda B Ditchfield Medical Research Endowment Fund and the Wenkart Foundation. Term placental samples were sourced and collected by the research midwives Sue Nisbet arid Sue Duggan. There are no conflicts of interest with respect to the authors of this work